Single-target answers: destroy, exile, or bounce whatever is about to kill you. Exile is at a premium in Commander, where regeneration and recursion are everywhere.
95%Swords to Plowshares InstantExile target creature. Its controller gains life equal to its power.
95%Path to Exile InstantExile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, t
83%Blasphemous Act SorceryThis spell costs {1} less to cast for each creature on the battlefield. Blasphemous Act deals 13 damage to each creature.$1.02
90%Beast Within InstantDestroy target permanent. Its controller creates a 3/3 green Beast creature token.$0.62
82%Generous Gift InstantDestroy target permanent. Its controller creates a 3/3 green Elephant creature token.$0.74
87%Boseiju, Who Endures Legendary Land{T}: Add {G}. Channel — {1}{G}, Discard this card: Destroy target artifact, enchantment, or nonbasic land an opponent controls. Th$48.70
88%Feed the Swarm SorceryDestroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.$0.22
90%Vandalblast SorceryDestroy target artifact you don't control. Overload {4}{R} (You may cast this spell for its overload cost. If you do, change "targ$1.38
90%Deadly Rollick InstantIf you control a commander, you may cast this spell without paying its mana cost. Exile target creature.$29.44
94%Assassin's Trophy InstantDestroy target permanent an opponent controls. Its controller may search their library for a basic land card, put it onto the batt$1.22
87%Abrade InstantChoose one — • Abrade deals 3 damage to target creature. • Destroy target artifact.$0.31
82%Pongify InstantDestroy target creature. It can't be regenerated. Its controller creates a 3/3 green Ape creature token.$2.76
92%Anguished Unmaking InstantExile target nonland permanent. You lose 3 life.$1.59
91%Austere Command SorceryChoose two — • Destroy all artifacts. • Destroy all enchantments. • Destroy all creatures with mana value 3 or less. • Destroy all$0.32
88%Farewell SorceryChoose one or more — • Exile all artifacts. • Exile all creatures. • Exile all enchantments. • Exile all graveyards.$6.15
91%Fell the Profane // Fell Mire Instant // LandFell the Profane: Destroy target creature or planeswalker. // Fell Mire: As this land enters, you may pay 3 life. If you don't, it$5.05
87%Stroke of Midnight InstantDestroy target nonland permanent. Its controller creates a 1/1 white Human creature token.
81%Rapid Hybridization InstantDestroy target creature. It can't be regenerated. That creature's controller creates a 3/3 green Frog Lizard creature token.$0.81
92%Terminate InstantDestroy target creature. It can't be regenerated.$0.34
92%Infernal Grasp InstantDestroy target creature. You lose 2 life.$0.36
91%Withering Torment InstantDestroy target creature or enchantment. You lose 2 life.$1.45
82%Untimely Malfunction InstantChoose one — • Destroy target artifact. • Change the target of target spell or ability with a single target. • One or two target c$8.76
84%Reality Shift InstantExile target creature. Its controller manifests the top card of their library. (That player puts the top card of their library ont$0.33
87%Witch Enchanter // Witch-Blessed Meadow Creature — Human Warlock // LandWitch Enchanter: When this creature enters, destroy target artifact or enchantment an opponent controls. // Witch-Blessed Meadow: $5.89
80%Rakdos Charm InstantChoose one — • Exile target player's graveyard. • Destroy target artifact. • Each creature deals 1 damage to its controller.$0.38
90%Reclamation Sage Creature — Elf ShamanWhen this creature enters, you may destroy target artifact or enchantment.$0.30
94%Putrefy InstantDestroy target artifact or creature. It can't be regenerated.$0.29
80%Loran of the Third Path Legendary Creature — Human ArtificerVigilance When Loran enters, destroy up to one target artifact or enchantment. {T}: You and target opponent each draw a card.$7.01
90%Damn SorceryDestroy target creature. A creature destroyed this way can't be regenerated. Overload {2}{W}{W} (You may cast this spell for its o$1.99
94%Go for the Throat InstantDestroy target nonartifact creature.$0.62
Prices and legality come from Scryfall. Every card here was scored by the same search that runs when you type a question.
