A board wipe destroys most or all creatures at once, which is how a Commander game gets reset when someone builds an unanswerable board. These are ranked by how well each card matches the job, with the cheapest and most-played ones first.
96%Blasphemous Act SorceryThis spell costs {1} less to cast for each creature on the battlefield. Blasphemous Act deals 13 damage to each creature.$1.02
92%Toxic Deluge SorceryAs an additional cost to cast this spell, pay X life. All creatures get -X/-X until end of turn.$4.40
80%Farewell SorceryChoose one or more — • Exile all artifacts. • Exile all creatures. • Exile all enchantments. • Exile all graveyards.$6.15
97%Damnation SorceryDestroy all creatures. They can't be regenerated.$21.06
88%Living Death SorceryEach player exiles all creature cards from their graveyard, then sacrifices all creatures they control, then puts all cards they e$5.96
94%Supreme Verdict SorceryThis spell can't be countered. Destroy all creatures.$2.30
81%Ruinous Ultimatum SorceryDestroy all nonland permanents your opponents control.$2.42
97%Wrath of God SorceryDestroy all creatures. They can't be regenerated.$4.15
88%Kindred Dominance SorceryChoose a creature type. Destroy all creatures that aren't of the chosen type.$4.94
88%Chain Reaction SorceryChain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.$0.35
94%Vanquish the Horde SorceryThis spell costs {1} less to cast for each creature on the battlefield. Destroy all creatures.$0.31
93%Fumigate SorceryDestroy all creatures. You gain 1 life for each creature destroyed this way.$0.31
91%Hour of Reckoning SorceryConvoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that $0.29
91%Cleansing Nova SorceryChoose one — • Destroy all creatures. • Destroy all artifacts and enchantments.$0.62
89%Organic Extinction SorceryImprovise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}$0.33
94%Decree of Pain SorceryDestroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way. Cycling {3}{B}{B} ({3}{B}{B}, $0.33
84%In Garruk's Wake SorceryDestroy all creatures you don't control and all planeswalkers you don't control.$3.17
81%Wave Goodbye SorceryReturn each creature without a +1/+1 counter on it to its owner's hand.$1.88
84%Crux of Fate SorceryChoose one — • Destroy all Dragon creatures. • Destroy all non-Dragon creatures.$3.32
92%Blood Money SorceryDestroy all creatures. For each nontoken creature destroyed this way, you create a tapped Treasure token.$3.02
83%Winds of Rath SorceryDestroy all creatures that aren't enchanted. They can't be regenerated.$0.33
81%Evacuation InstantReturn all creatures to their owners' hands.$0.30
96%Day of Judgment SorceryDestroy all creatures.$1.12
83%Split Up SorceryChoose one — • Destroy all tapped creatures. • Destroy all untapped creatures.$2.45
92%Nevinyrral's Disk ArtifactThis artifact enters tapped. {1}, {T}: Destroy all artifacts, creatures, and enchantments.$1.44
85%Liliana, Death's Majesty Legendary Planeswalker — Liliana+1: Create a 2/2 black Zombie creature token. Mill two cards. −3: Return target creature card from your graveyard to the battlefie$0.43
83%Perplexing Test InstantChoose one — • Return all creature tokens to their owners' hands. • Return all nontoken creatures to their owners' hands.$0.27
89%Ondu Inversion // Ondu Skyruins Sorcery // LandOndu Inversion: Destroy all nonland permanents. // Ondu Skyruins: This land enters tapped. {T}: Add {W}.$1.13
83%Final Showdown InstantSpree (Choose one or more additional costs.) + {1} — All creatures lose all abilities until end of turn. + {1} — Choose a creature$6.02
82%Starfall Invocation SorceryGift a card (You may promise an opponent a gift as you cast this spell. If you do, they draw a card before its other effects.) Des$1.01
Prices and legality come from Scryfall. Every card here was scored by the same search that runs when you type a question.